The new lipid-lowering drug Ezetimibe has clear curative effect and does not harm the liver. It is very suitable for 6 types of people with statin as a good partner

2022-08-07 0 By

Although hyperlipidemia, a chronic disease, does not have a severe impact on the human body on the surface, it may cause a series of serious consequences after a long development.Therefore, in recent years, more and more people begin to pay attention to hyperlipidemia, a potential health killer, and control it through drug treatment.However, the drugs used to treat hyperlipidemia in the past often produce relatively large pressure on the liver of the user. Because of the characteristics of hyperlipidemia, the cycle of taking medicine is often very long, which adds adverse factors to the treatment of many patients.The good news is that in recent years, ezetimibe, a new lipid-lowering drug, has come on the market. Its efficacy is clear and does not harm the liver. Today, we will talk about how this drug is better than traditional lipid-lowering drugs from the disease of hyperlipidemia, and who is suitable for taking this drug.First, what is hyperlipidemia, and what are its hazards?Hyperlipidemia, as the name implies, is an excess of fat in the blood.The fats in our blood, however, don’t exist alone. Instead, they bind with proteins to form lipoproteins that travel through our blood vessels.This creates a problem. As we all know, the relative molecular mass of proteins is very large, so lipids that bind to proteins tend to deposit on the walls of blood vessels during blood flow, forming plaque.These plaques can affect our health in two ways.First, as the plaque forms, it gets bigger and eventually blocks the entire blood vessel, preventing blood from flowing through it properly.Second, plaque formation can break away from the lining of blood vessels under the impact of blood. The plaque is a typical type of blood clot that moves around in the blood vessels, blocking the blood vessels when it passes through narrow areas.Our blood performs the important task of transporting nutrients to the organs and tissues in our body.If blood vessels are blocked, blood can’t get to the right parts of the body in time, and organs can’t work properly.If the blockage is in the carotid artery, the patient’s brain will not be able to receive blood in time, resulting in a brain infarction.It can range from partial paralysis and lengthy rehabilitation to outright death.Therefore, hyperlipidemia is a disease that may lead to serious consequences.Once the patient is diagnosed, it is necessary to immediately put into the fight against hyperlipidemia. Only by long-term treatment such as long-term medication can hyperlipidemia be effectively controlled and serious consequences prevented.Why do statins hurt the liver?There are many drugs to treat high blood lipids, the most familiar of which are statins.After a long period of development, the drug has formed a large family with three generations of drugs.Due to the maturity of pharmaceutical technology, these drugs are often not very expensive and patients can afford to take them for a long time.But statins may cause an increased burden on a user’s liver.We can start with how statins work.As we all know, the liver is an important organ in our body’s circulatory system, and it is also responsible for the synthesis of cholesterol.Statins act on the liver. They can bind to the receptor for cholesterol synthesizing protein in the liver and effectively intervene in the process of cholesterol synthesis, so as to control the cholesterol level in our body and further reduce the cholesterol level in the blood.Pharmacokinetics indicate that 90 percent of all tarantins are excreted in the stool as complete compounds within 24 hours of the user taking them.However, under the condition of long-term use, the accumulation of adverse effects of statins on patients can not be ignored.Many patients still have abnormally elevated transaminases after taking statins for a long time, which is one of the manifestations of liver damage.In addition, we can know from the mechanism of action of statins that statins have a relatively significant effect on patients with hyperlipidemia caused by cholesterol.However, cholesterol may not be the only substance that causes hyperlipidemia. High triglyceride and low density lipoprotein content may also cause hyperlipidemia.If a patient has high triglycerides and cholesterol levels, taking a statin alone won’t solve the problem, and taking two drugs at the same time, such as statin and beta, may put the body under greater burden.In addition, other studies have shown that statins may affect patients’ kinase indicators, patients may feel muscle soreness and even develop rhabdomyolysis in severe cases, which may cause long-term damage to patients’ health if not treated promptly.So the side effects of statins are something we should be concerned about.What is the difference between ezetimibe and statins?As we mentioned above, statins have a number of side effects that can be harmful to a patient’s health.But fortunately, statins are not the only drugs for treating hyperlipidemia. The development of science and technology has brought us a new drug for treating hyperlipidemia — Ezetimibe.The main component of Ezetimibe is an inhibitor of cholesterol acyltransferase.Why would you want to inhibit a substance called cholesterol acyltransferase?This is because acyltransferase plays an important role in the absorption, synthesis and storage of cholesterol in our bodies, and is essential for the accumulation of cholesterol in our bodies.If there was a substance that inhibited the activity of cholesterol acyltransferase, it would be very effective in lowering cholesterol levels in our bodies.That’s the idea behind Ezetimibe.But to find a suitable inhibitors is not an easy thing, the scientific research personnel in the process of synthesis of target compounds frustrated, eventually found after the successful synthesis of target compounds, before the clinical experiment, the content of cholesterol in the blood of rat control effect can be said to be minimal.Fortunately, the scientists found something in the byproduct of the synthesis of the target compound that controlled cholesterol levels in the rats’ blood. That was the cholesterol acyltransferase inhibitor they were looking for.After a lengthy series of clinical trials, the drug was finally approved for sale in the United States in 2002.There are a lot of differences between this drug and statins.First, it works in a completely different way than statins.Statins act on the liver and control cholesterol levels by interfering with the synthesis of cholesterol in the liver, which is bound to affect the normal functioning of the liver.Ezetimibe, on the other hand, works directly on the lining of the small intestine, just as our bodies absorb other substances, without causing any burden.With ezetimibe, the absorption of cholesterol in the mucous membrane of the small intestine is affected, and the cholesterol level in the patient naturally decreases.Compared to statins, ezetimibe imposes very little burden on the patient’s organs, especially the liver.In addition, ezetimibe is a more complex compound than statins.The synthesis process is much more complicated than statins.Moreover, the synthetic process is far less mature than that of statins, which has been developed for three generations. Therefore, this kind of drug is relatively expensive and has been produced by many domestic manufacturers.In addition, the drug also has something in common with statins in that it is suitable for patients with hyperlipidemia caused by high cholesterol, whereas other types of hyperlipidemia have very limited benefits.Therefore, when patients choose to take drugs, they must make reasonable and scientific choices according to their own conditions and doctors’ advice. Only in this way can they effectively control their own conditions.Iv. Which kinds of people are suitable for taking Ezetimibe?As we mentioned earlier, ezetimibe and statins are very different, they have different characteristics, and not everyone is suitable for ezetimibe and not everyone is suitable for statins, so let’s talk about who is suitable for ezetimibe.The first group of people suitable for ezetimibe are those with underlying liver disease, or those who have already suffered liver damage.Goal is to users of the liver of the role of statins, long-term taking statins, may further increase the pressure of the patients with liver, so for those who have liver problems, choose a smaller effect on the liver according to fold the mab can in the process of healing and at the same time protect your liver from further harm.The second group of people suitable for ezetimibe are those with high cholesterol.These people need to control their cholesterol levels in the short term, and ezetimibe, which directly controls cholesterol absorption from the source, can effectively help these people achieve their short-term goal of cholesterol control.The third group of people suitable for ezetimibe are those with relatively good economic conditions.Ezetimibe is currently a relatively expensive drug.Prices may change as patents expire and health care policies change, but for now, the more expensive ezetimibe is more suitable for patients who can afford it.The fourth group of people who are suitable for ezetimibe are those who need to take it for a long time.Although the effects of statins are limited, the side effects of statins become more apparent over time.The side effects of ezetimibe are relatively small compared with statins, and even long-term use of ezetimibe may have little impact on patients’ health. Therefore, ezetimibe is a better choice for those who need to take it for a long time.The fifth group of patients suitable for ezetimibe are those with hyperlipidemia due to multiple factors.Some patients have high triglycerides as well as high cholesterol.Typically, they take two types of lipid-controlling drugs — statins, which are used to control cholesterol levels, and beta, which is used to control triglycerides.But studies have shown that patients who take bate in combination with statins have significantly increased rates of muscle soreness and even rhabdomyolysis.So these patients can take ezetimibe, instead of statins, in combination with betas.The sixth group of people who are good candidates for ezetimibe are patients whose use is strongly recommended by doctors.Professional doctors will recommend more appropriate drugs according to the patient’s physical condition.Patients in the process of treatment, we must obey the doctor’s advice, the doctor’s advice is often more professional, but also the most helpful to the patient’s physical recovery.In addition, studies have shown that ezetimibe combined with statins can produce a one-plus-one effect that is greater than two in patients who are otherwise allowed to control their lipids.So ezetimibe is also a good partner for statins.To sum up, no matter taking statins or ezetimibe, patients must follow the doctor’s advice, choose the appropriate drugs according to the doctor’s advice, take the appropriate dose, and adhere to the treatment, so as to effectively control their blood lipids.For those who do not have hyperlipidemia friends, must start from the daily habits, so that their body to keep healthy, away from hyperlipidemia, away from vascular diseases.